Description

Loxapine-D8 Hydrochloride is a deuterated analog of the antipsychotic agent Loxapine, specifically labeled with eight deuterium atoms. This high-purity reference standard is critical for ensuring accurate and reliable results in quantitative analytical methods, particularly in pharmaceutical research and development. It is primarily utilized by analytical chemists and researchers in pharmaceutical, forensic, and clinical testing laboratories for applications such as method validation, pharmacokinetic studies, and bioanalytical assays.

Application

• Pharmaceutical Reference Standard: Serves as a certified internal standard for the precise quantification of Loxapine and its metabolites in complex biological matrices using LC-MS/MS and GC-MS.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for tracing and analyzing the absorption, distribution, metabolism, and excretion (ADME) profile of Loxapine in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Used to develop, optimize, and validate highly sensitive and specific analytical methods, improving accuracy and reducing matrix effects.
• Forensic and Clinical Toxicology: Enables the accurate detection and measurement of Loxapine in human plasma, serum, or urine for therapeutic drug monitoring or forensic investigations.
• Quality Control in Pharmaceutical Manufacturing: Employed in in-process testing and final product release to ensure the identity, potency, and purity of Loxapine-based drug products.
• Stability-Indicating Assays: Used in studies to assess the stability of Loxapine formulations under various stress conditions by providing a stable isotopic marker.

Basic Information

Product Name	Loxapine-D8 Hydrochloride
CAS No.	1246820-19-8
Molecular Formula	C18H10D8Cl2N2O • HCl
Molecular Weight	391.74 g/mol (for free base C18H10D8Cl2N2O)
Synonyms	2-Chloro-11-(4-methyl-1-piperazinyl)dibenzo[b,f][1,4]oxazepine-D8 Hydrochloride; Loxapine-d8 HCl; Loxapine (Octadeuterated) Hydrochloride; Loxitane-D8 Hydrochloride; CL-71563-d8; Oxilapine-D8 Hydrochloride; Loxapine-D8 Monohydrochloride
EINECS	Contact for details

Quality Control

Our Loxapine-D8 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and MS, to confirm isotopic purity, chemical purity, and structural identity. A comprehensive Certificate of Analysis (COA) is provided, detailing batch-specific results for isotopic enrichment, assay, and related substances. We support compliance with GMP/GLP guidelines for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Content)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.