Description

Nor Propranolol CAS NO 1246819-85-1 is a key pharmaceutical intermediate and metabolite of the β-blocker propranolol. This compound is of significant importance for analytical and research purposes, particularly in pharmacokinetic studies, drug metabolism research, and the development of bioanalytical methods. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of reference standards and diagnostic kits.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and qualification of propranolol and its metabolites in drug substances and products.
• Metabolite Studies: Critical for in-vitro and in-vivo metabolism studies to understand the pharmacokinetic profile and clearance pathways of propranolol.
• Bioanalytical Method Development: Serves as a critical standard in developing and validating HPLC, LC-MS, and GC-MS methods for biological samples (plasma, urine).
• Impurity Profiling: Employed to identify and control related substance impurities in propranolol hydrochloride active pharmaceutical ingredient (API) manufacturing.
• Clinical Research: Used in studies investigating individual metabolic variations and their impact on propranolol efficacy and safety.
• Forensic & Toxicology Analysis: Aids in the precise detection and measurement of propranolol and its metabolites in forensic investigations.

Basic Information

Product Name	Nor Propranolol
CAS No.	1246819-85-1
Molecular Formula	C₁₅H₂₁NO₂
Molecular Weight	247.33 g/mol
Synonyms	1-(1-Naphthyloxy)-3-(isopropylamino)-2-propanol, N-Desisopropylpropranolol; Desisopropyl Propranolol; Propranolol Impurity F; Propranolol Metabolite; 1-[(1-Naphthalenyl)oxy]-3-[(1-methylethyl)amino]-2-propanol; Norpropranolol; UNII-9M3H5W1A4Q
EINECS	Contact for details

Quality Control

Every batch of Nor Propranolol is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support its use in regulated environments. A detailed Certificate of Analysis (COA), including results for identity, purity, and related substances by validated chromatographic methods (HPLC), is supplied with each shipment to ensure traceability and compliance with your research or quality control requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.