Description

Demethyl Naproxen Sulfate is a high-purity pharmaceutical intermediate and analytical reference standard. This compound is of significant value in the research and development of novel non-steroidal anti-inflammatory drugs (NSAIDs) and their metabolites. It is primarily needed by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in drug development, impurity profiling, and pharmacokinetic studies.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced Naproxen derivatives and novel anti-inflammatory agents.
• Analytical Reference Standard: Used for the identification, assay, and impurity quantification of related substances in drug substances and finished products via HPLC, LC-MS, or GC-MS.
• Metabolite Studies: Serves as a critical standard in pharmacokinetic and metabolic pathway research for understanding drug disposition.
• Process Development & Validation: Essential for developing and validating manufacturing processes in compliance with cGMP guidelines.
• Quality Control & Assurance: Employed in in-house QC laboratories to ensure the purity and consistency of active pharmaceutical ingredients (APIs).
• Academic & Institutional Research: Used in universities and research institutes for medicinal chemistry and pharmacology projects.

Basic Information

Product Name	Demethyl Naproxen Sulfate
CAS No.	1246819-61-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Desmethyl Naproxen Sulfate; O-Desmethyl Naproxen Sulfate; Naproxen Metabolite Sulfate; 6-Methoxy-2-naphthylacetic acid, O-desmethyl, sulfate ester; DM-Naproxen Sulfate
EINECS	Contact for details

Quality Control

Our Demethyl Naproxen Sulfate is manufactured under strict quality systems. Every batch undergoes rigorous analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.