Description

7-Hydroxy Prochlorperazine-D8 is a high-purity, deuterium-labeled internal standard critical for advanced analytical applications. This compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities requiring precise and stable isotopic standards for method development and validation.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the precise quantification of prochlorperazine and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical Research & Development: Facilitates drug metabolism and pharmacokinetics (DMPK) studies, enabling accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME).
• Clinical Toxicology & Forensic Analysis: Supports the development of highly specific and sensitive assays for the detection and quantification of phenothiazine derivatives in forensic and clinical toxicology screenings.
• Bioanalytical Method Validation: Serves as a key component in the validation of bioanalytical methods according to regulatory guidelines (e.g., FDA, EMA) to ensure data integrity and reproducibility.
• Metabolite Identification & Profiling: Aids in the structural elucidation and profiling of hydroxylated metabolites of prochlorperazine during in vitro and in vivo studies.
• Quality Control in Manufacturing: Employed in the quality control of active pharmaceutical ingredients (APIs) and finished drug products to monitor impurity profiles and ensure batch consistency.

Basic Information

Product Name	7-Hydroxy Prochlorperazine-D8
CAS No.	1246819-57-7
Molecular Formula	C20H16D8ClN3OS
Molecular Weight	~389.96 g/mol
Synonyms	2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazin-7-ol-d8; Prochlorperazine-7-hydroxy-D8; Deuterated 7-Hydroxyprochlorperazine; 7-OH Prochlorperazine-d8; 7-Hydroxyprochlorperazine (deuterated); 1246819-57-7; 7-Hydroxy Prochlorperazine D8 Internal Standard
EINECS	Contact for details

Quality Control

Every batch of 7-Hydroxy Prochlorperazine-D8 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure exceptional purity and isotopic enrichment. Our quality assurance protocols are designed to meet the stringent requirements of analytical and pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), isotopic purity (by MS), and identification (by NMR & IR) is provided with each shipment to guarantee traceability and compliance with your research standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.