Description

11-(1-Piperazinyl-D8)-Dibenzo[B,F][1,4]Thiazepin-7-Ol CAS NO 1246819-53-3 is a deuterated derivative of a dibenzothiazepine compound, featuring a piperazine ring where eight hydrogen atoms have been replaced with deuterium. This deuteration is critical for enhancing metabolic stability and is a powerful tool in pharmaceutical research and development. This high-purity compound is primarily utilized by research scientists and process chemists in the pharmaceutical and biotechnology sectors for use as a stable isotope-labeled internal standard, a tracer in pharmacokinetic studies, and a key intermediate in the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for analytical method development and validation in drug testing.
• Metabolic and Pharmacokinetic (DMPK) Studies: Used as a stable isotope-labeled internal standard in LC-MS/MS and GC-MS analyses to ensure accurate quantification of the parent compound in biological matrices.
• Drug Discovery & Development: Acts as a crucial intermediate in the synthesis of deuterated drug candidates, leveraging the Deuterium Kinetic Isotope Effect (DKIE) to potentially improve metabolic profile and efficacy.
• Isotope Labeling Research: Employed in mechanistic studies and metabolic pathway elucidation within academic and industrial research laboratories.
• Quality Control & Assurance: Essential for ensuring batch-to-batch consistency and purity of non-deuterated active pharmaceutical ingredients (APIs) during manufacturing.

Basic Information

Product Name	11-(1-Piperazinyl-D8)-Dibenzo[B,F][1,4]Thiazepin-7-Ol
CAS No.	1246819-53-3
Molecular Formula	C19H13D8N3OS
Molecular Weight	347.50 g/mol
Synonyms	11-(1-Piperazinyl-D8)-Dibenzo[B,F][1,4]Thiazepin-7-Ol; 11-(Piperazin-1-yl-D8)dibenzo[b,f][1,4]thiazepin-7-ol; Deuterated Quetiapine Derivative; D8-Piperazinyl Dibenzo Thiazepinol; 7-Hydroxy-11-(piperazin-1-yl-D8)dibenzo[b,f][1,4]thiazepine
EINECS	Contact for details

Quality Control

Every batch of 11-(1-Piperazinyl-D8)-Dibenzo[B,F][1,4]Thiazepin-7-Ol is manufactured under strict quality management systems. We employ advanced analytical techniques including NMR (for deuterium incorporation verification), HPLC, and MS to ensure high chemical and isotopic purity. Comprehensive Certificates of Analysis (COA) detailing identity, assay, impurity profile, and residual solvents are provided and traceable to each production lot, supporting compliance with cGMP and ICH guidelines for research materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere or with desiccant for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure (D-incorporation ≥98%)
Purity (HPLC)	≥98.0%
Isotopic Purity (MS)	≥98 atom % D
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.