Description

Febuxostat-D9 CAS NO 1246819-50-0 is a deuterated isotopologue of the xanthine oxidase inhibitor Febuxostat, where nine hydrogen atoms are replaced by deuterium. This high-purity stable-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical material for pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers engaged in the development and quality control of febuxostat-based therapeutics.

Application

• Internal Standard for LC-MS/MS Analysis: Primary application as a stable isotope-labeled internal standard for the precise quantification of febuxostat in biological matrices (plasma, serum, urine) using liquid chromatography-tandem mass spectrometry.
• Pharmacokinetic and Bioequivalence Studies: Enables accurate measurement of drug concentration over time, critical for determining bioavailability, half-life, and bioequivalence of generic formulations.
• Drug Metabolism and Disposition Research: Used in ADME (Absorption, Distribution, Metabolism, Excretion) studies to track and quantify parent drug and potential metabolites without interference from endogenous compounds.
• Clinical Trial Support: Provides reliable data for drug monitoring in clinical trials, ensuring compliance with regulatory requirements for data integrity.
• Pharmaceutical Quality Control: Supports analytical method development and validation for the assay and impurity profiling of febuxostat in active pharmaceutical ingredients (APIs) and finished dosage forms.
• Forensic and Toxicological Analysis: Facilitates accurate detection and quantification of febuxostat in forensic investigations or cases of overdose.

Basic Information

Product Name	Febuxostat-D9
CAS No.	1246819-50-0
Molecular Formula	C16H7D9N2O3S
Molecular Weight	325.40 g/mol
Synonyms	2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic Acid-d9; Febuxostat (phenyl-d5, methyl-d4); Febuxostat-d9; Uloric-d9; TEI-6720-d9; Adenuric-d9; [2H9]-Febuxostat; 2-[3-Cyano-4-isobutoxyphenyl]-4-methylthiazole-5-carboxylic Acid-d9
EINECS	Contact for details

Quality Control

Our Febuxostat-D9 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (deuteration degree), chemical purity by HPLC, and confirmation of structure. We adhere to relevant industry standards for stable-labeled compounds, ensuring traceability and reliability for your regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98.0 atom % D
Chemical Purity	≥95.0% (by HPLC)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.