Description

n-Des(2-Pyridinyl)-n-(5-Carboxy-2-Thiazolyl) Lornoxicam is a key chemical intermediate and reference standard in the synthesis and analytical profiling of the non-steroidal anti-inflammatory drug (NSAID) Lornoxicam. This compound is critical for pharmaceutical research and development, enabling precise quality control and the development of novel drug formulations. It is primarily utilized by pharmaceutical manufacturers, analytical laboratories, and research institutions focused on anti-inflammatory therapeutics.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of the active pharmaceutical ingredient (API) Lornoxicam.
• Analytical Reference Standard: Used for method development, validation, and quality control testing (e.g., HPLC, LC-MS) of Lornoxicam APIs and finished dosage forms.
• Impurity Profiling: Serves as a specified impurity or degradation product standard to ensure drug purity and compliance with ICH guidelines.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research for Lornoxicam.
• Process Chemistry Research: Used in the development and optimization of synthetic routes for Lornoxicam production.
• Regulatory Submissions: Provides essential data and reference materials for drug master files (DMFs) and regulatory filings with agencies like the FDA and EMA.

Basic Information

Product Name	n-Des(2-Pyridinyl)-n-(5-Carboxy-2-Thiazolyl) Lornoxicam
CAS No.	1246819-40-8
Molecular Formula	C15H11N3O4S2
Molecular Weight	361.40 g/mol
Synonyms	Lornoxicam Impurity; Lornoxicam Related Compound; 2-[(5-Carboxy-1,3-thiazol-2-yl)amino]-N-hydroxy-2-thiophenecarboximidic Acid; 5-Carboxy-2-[[(2-thienylcarbonyl)amino]sulfonyl]thiazole; Despyridinyl Lornoxicam Carboxylic Acid; Lornoxicam Degradant; Lornoxicam Metabolite Analog
EINECS	Contact for details

Quality Control

Our n-Des(2-Pyridinyl)-n-(5-Carboxy-2-Thiazolyl) Lornoxicam is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; handle in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.