Description

Dehydro Mefloquine-D5 is a deuterated derivative of the antimalarial drug mefloquine, specifically designed for use as an internal standard in analytical chemistry. This high-purity reference material is critical for ensuring accurate quantification and method validation in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug development and bioanalysis.

Application

• Internal Standard for LC-MS/MS: Essential for the precise quantification of mefloquine and its metabolites in biological matrices such as plasma, serum, and urine.
• Pharmacokinetic Research: Used in studies to determine the absorption, distribution, metabolism, and excretion (ADME) profiles of mefloquine.
• Bioanalytical Method Development and Validation: Serves as a critical component in developing robust, reproducible, and regulatory-compliant analytical methods.
• Drug Metabolism Studies: Facilitates the identification and measurement of metabolic pathways and potential drug-drug interactions.
• Quality Control in Pharmaceutical Manufacturing: Employed in in-process testing and final product release assays for mefloquine-based pharmaceuticals.
• Clinical Trial Support: Provides reliable data for therapeutic drug monitoring and efficacy studies during clinical phases.

Basic Information

Product Name	Dehydro Mefloquine-D5
CAS No.	1246819-32-8
Molecular Formula	C₁₇H₁₁D₅F₆N₂O
Molecular Weight	~ 387.33 g/mol
Synonyms	Dehydro Mefloquine-d5; (R*,S*)-(±)-2,8-Bis(trifluoromethyl)-α-(2-piperidinyl)-4-quinolinemethanol-d5; Mefloquine Related Compound D-d5; Mefloquine Impurity D-d5; Mefloquine-d5 (dehydro); Deuterated Dehydro Mefloquine; Internal Standard for Mefloquine-d5
EINECS	Contact for details

Quality Control

Our Dehydro Mefloquine-D5 is manufactured under strict quality systems to ensure the highest standards of purity and isotopic enrichment, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), chemical purity, isotopic purity (D-content), and residual solvents. We adhere to relevant ICH guidelines for analytical validation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chemical Purity	≥ 95.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.