Description

Glycine-13C2 Ethyl Ester, Hydrochloride is a stable, isotopically labeled derivative of the fundamental amino acid glycine, specifically designed for advanced analytical and research applications. This compound is essential for use as an internal standard in mass spectrometry, enabling precise quantification and metabolic pathway tracing in complex biological matrices. It is a critical reagent for researchers and analytical laboratories in pharmaceutical development, clinical diagnostics, and metabolic research where high isotopic purity and chemical stability are paramount.

Application

• Mass Spectrometry Internal Standard: Used for the accurate quantification of glycine and related metabolites in LC-MS and GC-MS analyses.
• Metabolic Flux Analysis (MFA): Serves as a 13C-labeled tracer to study central carbon metabolism and amino acid biosynthesis pathways in cells and organisms.
• Proteomics & Stable Isotope Labeling by Amino acids in Cell culture (SILAC): Enables the study of protein turnover, synthesis rates, and post-translational modifications.
• Pharmaceutical Research: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of drug molecules and their metabolites.
• Clinical Diagnostics: Facilitates the development of highly specific and sensitive assays for inborn errors of metabolism involving glycine.
• NMR Spectroscopy: Acts as a 13C-enriched standard for nuclear magnetic resonance studies of molecular structure and dynamics.
• Chemical Synthesis: Provides a labeled building block for the synthesis of more complex isotopically labeled peptides, peptidomimetics, and other organic compounds.

Basic Information

Product Name	Glycine-13C2 Ethyl Ester, Hydrochloride
CAS No.	1246819-31-7
Molecular Formula	C413C2H12ClNO2
Molecular Weight	154.57 g/mol (for 13C2 isotopologue)
Synonyms	Ethyl 2-aminoacetate-13C2 hydrochloride; Glycine-13C2 ethyl ester HCl; Aminoacetic-13C2 acid ethyl ester hydrochloride; Ethyl glycinate-13C2 hydrochloride; 13C2-Glycine ethyl ester hydrochloride; 2-Aminoacetic-13C2 acid ethyl ester hydrochloride; Ethyl aminoacetate-13C2 hydrochloride
EINECS	Contact for details

Quality Control

Our Glycine-13C2 Ethyl Ester, Hydrochloride is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment, chemical purity, and identity confirmation. We adhere to relevant industry standards for labeled compounds, and our quality protocols are designed to meet the rigorous demands of pharmaceutical and clinical research.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry place. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (13C2)	≥ 99 atom % 13C
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.