Description

n-Desmethyl Perazine-D8 is a high-purity, deuterium-labeled internal standard critical for precise quantitative analysis in modern bioanalytical and pharmacokinetic studies. This stable isotope-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based assays, particularly for minimizing matrix effects and correcting for analyte loss. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology units for the development and validation of sensitive LC-MS/MS methods targeting perazine and its metabolites.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound for the accurate quantification of perazine and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical R&D & Metabolism Studies: Enables precise pharmacokinetic (PK) and pharmacodynamic (PD) profiling, aiding in drug discovery and development stages for antipsychotic agents.
• Forensic and Clinical Toxicology: Used in method development for the detection and confirmation of perazine in forensic analysis and therapeutic drug monitoring (TDM).
• Bioanalytical Method Validation: Provides the necessary isotopic purity to meet regulatory guidelines (e.g., FDA, EMA) for assay validation, ensuring specificity, accuracy, and precision.
• Stable Isotope Dilution Assays: Fundamental for high-accuracy quantification techniques that require compensation for sample preparation variability and instrument drift.

Basic Information

Product Name	n-Desmethyl Perazine-D8
CAS No.	1246819-14-6
Molecular Formula	C19H14D8N2S
Molecular Weight	318.51 g/mol
Synonyms	Perazine-d8 (N-Desmethyl); 10-[3-(4-Methylpiperazin-1-yl)propyl]-10H-phenothiazine-d8 (N-Desmethyl); 1-Desmethyl Perazine-d8; Norperazine-d8; Deuterated n-Desmethyl Perazine; Perazine Metabolite-d8; Stable Isotope Labeled n-Desmethyl Perazine
EINECS	Contact for details

Quality Control

Every batch of n-Desmethyl Perazine-D8 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data from NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥98% by HPLC), isotopic enrichment (typically ≥98 atom % D), and the absence of critical unlabeled impurities. Our quality commitment ensures reliability for your most demanding analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 98%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.