Description

o-Benzyl Posaconazole-D4 is a deuterated isotopologue of a key posaconazole intermediate, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative analyses, particularly in regulated environments. It is primarily used by pharmaceutical researchers, analytical laboratories, and quality control departments involved in the development, manufacturing, and testing of antifungal drugs.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of posaconazole and related compounds in bioanalytical studies, including pharmacokinetic and pharmacodynamic research.
• Pharmaceutical Impurity Profiling: Used as a reference standard to identify and quantify process-related impurities and degradation products in active pharmaceutical ingredient (API) batches.
• Metabolite Studies: Facilitates the detection and measurement of posaconazole metabolites in biological matrices during drug metabolism and excretion studies.
• Method Development and Validation: Serves as a stable, non-interfering standard for developing and validating robust analytical methods in compliance with ICH and FDA guidelines.
• Quality Control Testing: Ensures batch-to-batch consistency and purity of posaconazole API through comparative analytical techniques.
• Stable Isotope Labeling Research: Used in mechanistic studies to trace molecular pathways and understand drug behavior in biological systems.

Basic Information

Product Name	o-Benzyl Posaconazole-D4
CAS No.	1246818-95-0
Molecular Formula	C37H38D4F2N8O4
Molecular Weight	700.79 g/mol (for deuterated form)
Synonyms	Posaconazole D4 o-Benzyl Derivative; 4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-benzyl-3-hydroxypent-4-yn-1-yl-d4]-1,2,4-triazol-3-one; Deuterated o-Benzyl Posaconazole; Posaconazole-d4 Benzyl Intermediate; (2S,3S)-2-Benzyl-3-hydroxypent-4-yn-1-yl-d4 Posaconazole Derivative
EINECS	Contact for details

Quality Control

Our o-Benzyl Posaconazole-D4 is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for analytical standards. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic purity (D4 content), and identity confirmation via advanced spectroscopic methods. We adhere to relevant industry standards for reference materials, and specifications can be tailored to meet specific research or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D4)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.