Description

(4S,5R)-4-(Fluoromethyl)-4,5-Dihydro-5-[4-(Methylsulfonyl)Phenyl]-2-Phenyl-Oxazole-D3 is a high-purity, deuterated oxazole derivative designed for advanced research and development. This compound is a critical building block and intermediate in the synthesis of novel pharmaceuticals, particularly for its role in medicinal chemistry and drug discovery programs. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries. The CAS number for this compound is 1246818-78-9.

Application

This deuterated oxazole derivative serves as a sophisticated intermediate with specific applications in advanced chemical synthesis.

• Pharmaceutical Intermediate: A key building block in the research and development of new active pharmaceutical ingredients (APIs), particularly for targeted therapies.
• Deuterated Compound Synthesis: Used in the preparation of deuterium-labeled analogs of drug candidates for metabolic stability studies and pharmacokinetic (PK) research.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize the biological activity and properties of lead compounds.
• Process Chemistry Development: Serves as a critical intermediate in scaling up synthetic routes from laboratory to pilot plant scale.
• Biochemical Tool Compound: Potential use in developing probes for studying biological pathways and enzyme mechanisms.

Basic Information

Product Name	(4S,5R)-4-(Fluoromethyl)-4,5-Dihydro-5-[4-(Methylsulfonyl)Phenyl]-2-Phenyl-Oxazole-D3
CAS No.	1246818-78-9
Molecular Formula	C18H14D3FNO3S
Molecular Weight	349.41 g/mol
Synonyms	4-(Fluoromethyl)-4,5-dihydro-5-[4-(methylsulfonyl)phenyl]-2-phenyl-oxazole-d3 (4S,5R)-; (4S,5R)-4-(Fluoromethyl)-5-(4-(methylsulfonyl)phenyl)-2-phenyl-4,5-dihydrooxazole-d3; Deuterated Oxazole Intermediate; 4,5-Dihydro-2-phenyl-4-(fluoromethyl)-5-[4-(methylsulfonyl)phenyl]oxazole-d3 (stereo: 4S,5R); CAS 1246818-78-9
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. We maintain strict protocols to ensure high chemical purity and isomeric integrity, which are critical for research reproducibility. Specifications are verified using advanced analytical techniques including HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Deuterium Incorporation (MS)	≥ 98 atom % D
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.