Description

Vinblastine-D3 Sulfate is a deuterated isotopologue of the established vinca alkaloid, Vinblastine Sulfate, specifically labeled with three deuterium atoms. This high-purity reference standard is critical for ensuring analytical accuracy and reliability in quantitative bioanalysis, where it serves as an internal standard to correct for matrix effects and instrument variability. It is an essential tool for pharmaceutical R&D, clinical research, and quality control laboratories focused on oncology drug development, therapeutic drug monitoring, and pharmacokinetic studies of vinblastine.

Application

• Primary use as an Internal Standard (IS) in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) bioanalytical methods for Vinblastine quantification.
• Pharmacokinetic (PK) and pharmacodynamic (PD) studies in preclinical and clinical research for accurate measurement of drug concentration in biological matrices (plasma, serum, tissue).
• Metabolite identification and profiling studies using deuterium-labeled analogs to track drug pathways.
• Method development and validation in accordance with regulatory guidelines (FDA, EMA) for bioanalytical assays.
• Quality control and stability testing of Vinblastine Sulfate drug substances and finished pharmaceutical products.
• Supporting research in drug resistance mechanisms and combination therapies in oncology.

Basic Information

Product Name	Vinblastine-D3 Sulfate
CAS No.	1246818-72-3
Molecular Formula	C46H55D3N4O13 • H2SO4
Molecular Weight	~ 909.0 g/mol (for free base C46H55D3N4O13)
Synonyms	Vincaleukoblastine-d3 Sulfate; Vinblastine (methyl-d3) Sulfate; 3',4'-Didehydro-4'-deoxy-3'-(methyl-d3)-vincaleukoblastine Sulfate; [Methyl-d3]-Vinblastine Sulfate; VLB-d3 Sulfate; Isotopically Labeled Vinblastine Sulfate; Deuterated Vinblastine Sulfate; Internal Standard for Vinblastine
EINECS	Contact for details

Quality Control

Our Vinblastine-D3 Sulfate is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing critical parameters including isotopic enrichment (≥98% D3), chemical purity (by HPLC), and confirmation of structure. We support compliance with GMP/GLP principles for reference standards used in regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Isotopic Purity (D3)	≥ 98%
Assay (HPLC)	≥ 95% (on anhydrous basis)
Chemical Purity (HPLC)	≥ 98%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.