Description

Iso-Colchicine-D3 is a stable isotope-labeled analog of the natural alkaloid colchicine, specifically deuterated at three positions. This high-purity compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical workflows. It is a critical material for pharmaceutical research, forensic toxicology, and clinical laboratories conducting pharmacokinetic studies, drug metabolism research, and therapeutic drug monitoring of colchicine.

Application

• Internal Standard for LC-MS/MS: Primary application as a deuterated internal standard for the precise quantification of colchicine in biological matrices (plasma, serum, urine).
• Pharmacokinetic & Bioavailability Studies: Enables accurate tracking of colchicine absorption, distribution, metabolism, and excretion (ADME) in clinical and preclinical research.
• Forensic & Clinical Toxicology: Used in assays to confirm colchicine exposure or poisoning with high specificity and sensitivity.
• Drug Metabolism Research (DMPK): Facilitates the identification and quantification of colchicine metabolites in vitro and in vivo.
• Method Development & Validation: Serves as a critical reference material for developing and validating robust analytical methods in compliance with GLP/GCP guidelines.
• Quality Control in Pharmaceutical Manufacturing: Can be employed in impurity profiling and assay development for colchicine-based drug products.

Basic Information

Product Name	Iso-Colchicine-D3
CAS No.	1246818-69-8
Molecular Formula	C22H22D3NO6
Molecular Weight	402.46 g/mol (approximate)
Synonyms	Colchicine-d3; (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide-d3; Deuterated Colchicine; Colchicine Internal Standard; Isotopically Labeled Colchicine; Colchicine-D3; Iso-colchicine deuterated; [D3]-Colchicine
EINECS	Contact for details

Quality Control

Every batch of Iso-Colchicine-D3 is manufactured and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) detailing isotopic purity (D-enrichment), chemical purity (by HPLC), and identity confirmation (by NMR and MS). Our quality commitment ensures the material meets the stringent requirements for use in regulated bioanalytical methods, supporting research that demands reliable and reproducible data.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 99.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.