Description

Tiletamine-D5 Hydrochloride is a deuterated isotopologue of the dissociative anesthetic agent Tiletamine, specifically labeled with five deuterium atoms. This stable isotope-labeled compound is of critical importance for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical results. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and forensic toxicology units for applications in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and clinical research.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound in the quantitative bioanalysis of Tiletamine and its metabolites in biological matrices such as plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Used in pharmaceutical R&D to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of Tiletamine.
• Forensic and Clinical Toxicology: Enables precise identification and quantification of Tiletamine in forensic casework and clinical overdose scenarios.
• Veterinary Pharmaceutical Research: Supports analytical method development for monitoring Tiletamine, a component in veterinary anesthetic combinations.
• Reference Material for Method Validation: Provides a certified standard for validating and calibrating analytical instruments and procedures in compliance with GLP guidelines.

Basic Information

Product Name	Tiletamine-D5 Hydrochloride
CAS No.	1246818-12-1
Molecular Formula	C12H11D5Cl2N2O
Molecular Weight	284.20 g/mol
Synonyms	2-(Ethyl-D5-amino)-2-(2-thienyl)cyclohexanone Hydrochloride; Tiletamine-d5 HCl; Tiletamine (ethyl-D5) Hydrochloride; CL-634-d5 Hydrochloride; Tiletamine (pentadeutero) Hydrochloride; (±)-Tiletamine-D5 Hydrochloride; 2-(Ethyl-d5-amino)-2-thiophen-2-ylcyclohexan-1-one Hydrochloride
EINECS	Contact for details

Quality Control

Our Tiletamine-D5 Hydrochloride is manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment, chemical purity, and identity confirmation via advanced spectroscopic techniques. We adhere to relevant industry standards for high-purity reference materials to support your compliance with GLP and ISO 17025 requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.