Description

Pyrazinamide-15N,D3 is a stable isotope-labeled analog of the first-line anti-tuberculosis drug, Pyrazinamide, specifically enriched with Nitrogen-15 and deuterium (D). This compound is essential for advanced pharmacokinetic and metabolic studies, providing unparalleled accuracy in mass spectrometry-based quantification and pathway analysis. It is a critical material for pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on drug metabolism, bioanalytical method development, and clinical research.

Application

• Internal Standard for LC-MS/MS: Serves as a high-purity, non-interfering internal standard for the precise quantification of Pyrazinamide and its metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracer studies to elucidate metabolic pathways, identify metabolites, and study the absorption, distribution, metabolism, and excretion (ADME) profile of Pyrazinamide.
• Bioanalytical Method Development: Enables the development and validation of highly sensitive and specific mass spectrometric assays for therapeutic drug monitoring (TDM) and clinical trials.
• Stable Isotope Labeling Studies: Facilitates mechanistic studies in medicinal chemistry and biochemistry where tracking the fate of specific atoms within the molecule is required.
• Quality Control Reference Material: Acts as a certified reference standard for ensuring the accuracy and reliability of analytical results in quality control laboratories.

Basic Information

Product Name	Pyrazinamide-15N,D3
CAS No.	1246817-81-1
Molecular Formula	C5H2D315N3O
Molecular Weight	126.11 g/mol (approximate)
Synonyms	Pyrazinecarboxamide-15N,d3; Deuterated Pyrazinamide-15N; [15N,d3]-Pyrazinamide; PZA-15N,d3; 2-Pyrazinecarboxamide-15N,d3; Pyrazinoic acid amide-15N,d3; Isotopically labeled Pyrazinamide; Stable isotope-labeled Tuberculostatic
EINECS	Contact for details

Quality Control

Every batch of Pyrazinamide-15N,D3 CAS NO 1246817-81-1 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, verified by advanced spectroscopic and chromatographic techniques including NMR, HPLC, and Mass Spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific data for identity, purity (HPLC assay), isotopic enrichment, and residual solvents, ensuring compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % 15N; ≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.