Description

5-Hydroxy Rosiglitazone-D4 is a high-purity, deuterium-labeled analog of the active metabolite of Rosiglitazone, a thiazolidinedione-class pharmaceutical. This stable isotope-labeled compound is essential for precise quantitative analysis and metabolic studies, serving as a critical internal standard in bioanalytical research. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on pharmacokinetics, drug metabolism, and analytical method development.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the accurate quantification of 5-Hydroxy Rosiglitazone and related metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Facilitates precise tracking of drug metabolite formation, distribution, and elimination in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Critical for developing robust, sensitive, and specific HPLC or UPLC mass spectrometry assays in compliance with GLP guidelines.
• Pharmacological Research: Supports studies investigating the metabolic pathways and mechanisms of action of thiazolidinedione drugs.
• Clinical Trial Support: Enables reliable measurement of drug metabolite levels in patient samples during clinical phases.
• Reference Material: Serves as a certified reference material (CRM) for calibrating analytical instruments and ensuring data integrity.

Basic Information

Product Name	5-Hydroxy Rosiglitazone-D4
CAS No.	1246817-46-8
Molecular Formula	C18H15D4N3O4S
Molecular Weight	361.43 g/mol
Synonyms	5-Hydroxy Rosiglitazone-d4; 5-Hydroxy-4-[[4-[2-(methyl-d3)pyridinyl]methoxy]phenyl]methyl]-2,4-thiazolidinedione; Deuterated 5-Hydroxy Rosiglitazone; Rosiglitazone Metabolite-d4; 5-OH-Rosiglitazone-D4; BRL 49653 Metabolite-d4; Avandia Metabolite-d4 (Deuterated)
EINECS	Contact for details

Quality Control

Every batch of 5-Hydroxy Rosiglitazone-D4 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment. Our quality assurance protocols are designed to meet the stringent requirements of research and bioanalysis. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for assay, isotopic purity, and related substances is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Enrichment)	≥98.0 atom % D
Chemical Purity (by HPLC)	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.