Description

Raltegravir-D3, Potassium Salt is a deuterated isotopologue of the antiretroviral drug Raltegravir, specifically labeled with three deuterium atoms. This high-purity reference standard is critical for ensuring the accuracy and reliability of bioanalytical methods in pharmacokinetic and metabolism studies. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and quality control departments for use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) analysis.

Application

• Primary use as an Internal Standard (IS) for the quantitative bioanalysis of Raltegravir in biological matrices (plasma, serum, tissue) via LC-MS/MS.
• Essential for conducting pharmacokinetic (PK) and drug metabolism studies during drug development and clinical trials.
• Enables highly accurate and precise quantification, correcting for matrix effects and instrument variability in analytical assays.
• Supports method development and validation in accordance with regulatory guidelines (e.g., FDA, EMA).
• Used in doping control analysis and forensic toxicology for the specific detection of Raltegravir.
• Facilitates stable isotope dilution assays to ensure the highest level of analytical confidence.

Basic Information

Product Name	Raltegravir-D3, Potassium Salt
CAS No.	1246816-98-7
Molecular Formula	C20H18D3FN6O5•K
Molecular Weight	507.53 g/mol (approx.)
Synonyms	Raltegravir-d3 Potassium Salt; Potassium Raltegravir-d3; N-[(4-Fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-2-[1-methyl-1-[[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino]ethyl]-6-oxo-4-pyrimidinecarboxamide-d3 Potassium Salt; Isentress-d3 Potassium Salt; MK-0518-d3 Potassium Salt; (4R,12aS)-N-[(4-Fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-2-[1-methyl-1-[[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino]ethyl]-6-oxo-4-pyrimidinecarboxamide-d3 Potassium Salt
EINECS	Contact for details

Quality Control

Our Raltegravir-D3, Potassium Salt is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, isotopic purity (D-enrichment), chemical purity, and residual solvents. We adhere to relevant GMP and ISO 9001 principles for reference material production, ensuring traceability and consistency for our global clientele in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is hygroscopic (moisture-sensitive); the original container should be kept in a dry environment and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 99.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.