Description

Tolcapone-D4 CAS NO 1246816-93-2 is a deuterated analog of Tolcapone, a selective and reversible catechol-O-methyltransferase (COMT) inhibitor. This stable isotope-labeled compound is essential for high-precision analytical applications, serving as a critical internal standard for accurate quantification. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS and GC-MS analysis in bioanalytical studies.
• Quantitative analysis of Tolcapone and its metabolites in biological matrices (e.g., plasma, serum, urine).
• Pharmacokinetic (PK) and pharmacodynamic (PD) research in drug development.
• Drug metabolism and disposition (DMPK) studies to understand metabolic pathways.
• Method development and validation for regulatory compliance in pharmaceutical analysis.
• Quality control and assurance in the manufacturing of active pharmaceutical ingredients (APIs).
• Use in clinical research for monitoring drug levels and ensuring therapeutic efficacy.

Basic Information

Product Name	Tolcapone-D4
CAS No.	1246816-93-2
Molecular Formula	C14H7D4NO5
Molecular Weight	273.26 g/mol (approximate)
Synonyms	3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone-D4; 3,4-Dihydroxy-5-nitro-4'-methylbenzophenone-D4; (3,4-Dihydroxy-5-nitro-phenyl)-(4-methyl-phenyl)-methanone-D4; Tolcapone-d4; Ro 40-7592-d4; COMT Inhibitor-d4; Stable Isotope Labeled Tolcapone; Tolcapone Internal Standard
EINECS	Contact for details

Quality Control

Our Tolcapone-D4 is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity. Each batch is analyzed using advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, chemical purity, and isotopic enrichment. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to brownish powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.