Description

Acipimox-D4 CAS NO 1246816-28-3 is a deuterated analog of the lipid-lowering agent Acipimox, specifically labeled with four deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical material for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in the development and validation of LC-MS/MS assays.

Application

• Internal Standard for LC-MS/MS Analysis: Primary use as a quantitative reference standard in the bioanalysis of Acipimox in biological matrices (plasma, serum, urine).
• Drug Metabolism and Pharmacokinetics (DMPK): Enables precise tracking of the parent drug's absorption, distribution, metabolism, and excretion (ADME) profiles.
• Clinical Trial Support: Critical for ensuring data integrity in bioanalytical testing during all phases of clinical development for Acipimox or related compounds.
• Method Development and Validation: Serves as a key component in establishing robust, regulatory-compliant (FDA, EMA) analytical methods.
• Stable Isotope Dilution Assays: Used in high-precision quantification techniques to minimize matrix effects and ion suppression.
• Reference Material for Certified Standards: Acts as a starting material for the preparation of certified reference materials (CRMs) with defined isotopic purity.

Basic Information

Product Name	Acipimox-D4
CAS No.	1246816-28-3
Molecular Formula	C6H2D4N2O3
Molecular Weight	~158.14 g/mol (deuterated form)
Synonyms	5-Methylpyrazine-2-carboxylic acid 4-oxide-D4; Acipimox (tetradeuterated); Acipimox-d4; [2H4]-Acipimox; 5-Methylpyrazinecarboxylic acid 4-oxide-d4; Tetradeuteroacipimox; Olbetam-D4 (labeled analog); K-9321-D4
EINECS	Contact for details

Quality Control

Every batch of Acipimox-D4 is manufactured and controlled under a strict quality management system. We provide comprehensive analytical data to support its use in regulated environments. Specifications typically include isotopic purity (e.g., ≥98% D4), chemical purity (by HPLC), and confirmation of structure (by NMR and MS). A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to expected mass
Isotopic Purity (D4)	≥98.0%
Chemical Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.