Description

5-Acetylamino-6-Amino-3-Methyluracil-D3 Hydrate is a deuterated derivative of a key uracil-based intermediate, distinguished by the strategic incorporation of deuterium atoms. This compound is of significant value in pharmaceutical research and development, particularly for its role in the synthesis of deuterated drug candidates to enhance metabolic stability and pharmacokinetic profiles. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including kinase inhibitors and other targeted agents.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of deuterated active pharmaceutical ingredients (APIs) for clinical research.
• Deuterated Drug Development: Used to create isotopically labeled analogs of drug candidates to study metabolic pathways and improve drug half-life.
• Biochemical Research: Serves as a precursor in studies involving nucleoside/nucleotide chemistry and enzyme inhibition mechanisms.
• Reference Standard: Employed as an analytical standard in mass spectrometry and NMR for quantification and method validation in deuterium-labeled compound analysis.
• Preclinical Studies: Utilized in the preparation of compounds for pharmacokinetic (PK), pharmacodynamic (PD), and toxicology evaluations.

Basic Information

Product Name	5-Acetylamino-6-Amino-3-Methyluracil-D3 Hydrate
CAS No.	1246816-23-8
Molecular Formula	C8H8D3N4O3 • xH2O
Molecular Weight	Contact for details
Synonyms	5-Acetamido-6-amino-3-methyluracil-d3; 6-Amino-5-acetylamino-3-methyluracil-d3; 3-Methyl-5-acetylamino-6-aminouracil-d3; 5-(Acetylamino)-6-amino-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione-d3; Deuterated AAMU; AAMU-d3; [2H3]-5-Acetylamino-6-amino-3-methyluracil
EINECS	Contact for details

Quality Control

Our 5-Acetylamino-6-Amino-3-Methyluracil-D3 Hydrate is manufactured under strict quality systems to ensure high chemical purity and isotopic enrichment. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chemical purity (by HPLC), deuterium incorporation (by NMR/MS), and residual solvent content. We adhere to cGMP principles for pharmaceutical intermediates, ensuring reliable consistency and traceability for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Incorporation (NMR/MS)	≥ 98 atom % D
Water Content (KF)	Contact for details
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.