Description

4-Amino-1-((2R,5S)-2-((tert-Butyldimethylsilyloxy)Methyl)-1,3-Oxathiolan-5-Yl)-5-Fluoropyrimidin-2(1H)-One-13C,15N2 is a high-purity, isotopically labeled nucleoside analog intermediate, specifically designed for advanced pharmaceutical research and development. This compound is critical for metabolic and pharmacokinetic studies, providing the necessary isotopic tracers for precise analytical detection. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) engaged in the development of antiviral therapeutics and diagnostic agents.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for quality control and method validation in the production of antiviral drugs.
• Metabolic Pathway Tracing: The 13C and 15N2 labels enable detailed studies of drug absorption, distribution, metabolism, and excretion (ADME) using mass spectrometry.
• Active Pharmaceutical Ingredient (API) Synthesis: A key chiral building block in the multi-step synthesis of novel nucleoside-based antiviral agents.
• Biochemical Research: Used in enzymatic studies to investigate the mechanism of action of reverse transcriptase and other viral polymerase inhibitors.
• Diagnostic Development: Employed in the creation of labeled probes and assays for detecting viral load and resistance.

Basic Information

Item	Detail
Product Name	4-Amino-1-((2R,5S)-2-((tert-Butyldimethylsilyloxy)Methyl)-1,3-Oxathiolan-5-Yl)-5-Fluoropyrimidin-2(1H)-One-13C,15N2
CAS No.	1246816-05-6
Molecular Formula	C1313CH24FN315N2O3SSi
Molecular Weight	Contact for details
Synonyms	Lamivudine Impurity 13C,15N2 (TBDMS derivative); FTC-related intermediate-13C,15N2; 2'-Deoxy-3'-thiacytidine derivative-13C,15N2; (-)-BCH-189 TBDMS ether-13C,15N2; 4-Amino-1-((2R,5S)-2-((tert-butyldimethylsilyloxy)methyl)-1,3-oxathiolan-5-yl)-5-fluoropyrimidin-2(1H)-one-13C,15N2; Isotopically labeled nucleoside precursor; [13C,15N2]-Labeled oxathiolane pyrimidinone
EINECS	Contact for details

Quality Control

Every batch of this isotopically labeled compound is produced and analyzed under strict GMP-like conditions to ensure identity, purity, and isotopic enrichment meet the exacting standards required for pharmaceutical research. Comprehensive testing includes chiral purity, isotopic abundance, and impurity profiling. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for assay, radiochemical purity, and specified impurities.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment (13C)	≥ 99 atom %
Isotopic Enrichment (15N)	≥ 98 atom %
Chiral Purity (Chiral HPLC)	≥ 99.0%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.