Description

Piritramide-D10 is a deuterated analog of the potent opioid analgesic piritramide, specifically labeled with ten deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical results. It is primarily utilized by pharmaceutical research laboratories, forensic toxicology departments, and contract research organizations (CROs) for method development, pharmacokinetic studies, and drug metabolism research.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of piritramide and its metabolites in complex biological matrices such as plasma, serum, and urine.
• Pharmacokinetic and Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical research.
• Forensic and Clinical Toxicology: Supports reliable screening and confirmation of piritramide in forensic investigations and clinical overdose cases.
• Drug Metabolism Research: Used to identify and quantify metabolite profiles, aiding in the understanding of a drug's metabolic pathways.
• Method Development and Validation: Serves as a key component in developing robust, sensitive, and specific analytical methods compliant with regulatory guidelines (e.g., FDA, EMA).
• Quality Control in Pharmaceutical Manufacturing: Can be employed in impurity profiling and stability testing of piritramide-based pharmaceutical products.

Basic Information

Product Name	Piritramide-D10
CAS No.	1246815-72-4
Molecular Formula	C27H30D10N4O2
Molecular Weight	~446.7 g/mol
Synonyms	Piritramide-d10; 1'-(3-Cyano-3,3-diphenylpropyl)-[1,4'-bipiperidine]-4'-carboxamide-d10; Dipidolor-d10; Pirinitramide-d10; R 3365-d10; Deuterated Piritramide; Piritramide (phenyl-d5, piperidine-d5)
EINECS	Contact for details

Quality Control

Our Piritramide-D10 is manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical integrity, meeting the stringent requirements for analytical reference standards. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment, chemical purity, and identity confirmation via advanced spectroscopic techniques. We support compliance with GMP and ISO 9001 standards for research and diagnostic use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Enrichment)	≥98.0 atom % D
Chemical Purity (HPLC)	≥95.0%
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.