Description

n-Isopropyl Carvedilol-D6 is a deuterated isotopologue of a key carvedilol derivative, specifically labeled on the isopropyl moiety. This compound is of significant value as a high-purity internal standard for quantitative bioanalytical methods, ensuring accuracy and reliability in pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug development and regulatory compliance testing.

Application

• Primary use as an Internal Standard (IS) in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and GC-MS analysis of carvedilol and its metabolites.
• Critical for Bioanalytical Method Development and Validation (BA/BV) in support of preclinical and clinical trials.
• Enables precise Pharmacokinetic (PK) and Toxicokinetic (TK) profiling by correcting for instrument variability and sample preparation losses.
• Facilitates Drug Metabolism and Pharmacokinetics (DMPK) studies to understand the absorption, distribution, metabolism, and excretion (ADME) of carvedilol.
• Used in Stability-Indicating Assay Methods to monitor drug substance and product degradation over time.
• Supports Regulatory Submissions to agencies like the FDA and EMA by providing robust, reproducible analytical data.

Basic Information

Product Name	n-Isopropyl Carvedilol-D6
CAS No.	1246815-40-6
Molecular Formula	C24H30D6N2O4
Molecular Weight	~ 414.58 g/mol
Synonyms	Carvedilol D6 (isopropyl-d6); 1-(Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol-d6; (±)-[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl][2-(2-methoxyphenoxy)ethyl]amine-d6; Carvedilol-d6 (isopropyl labeled); Deuterated Carvedilol Internal Standard; n-Isopropyl Carvedilol Deuterated Standard
EINECS	Contact for details

Quality Control

Every batch of n-Isopropyl Carvedilol-D6 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization by NMR, MS, and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and confirming the absence of unlabeled compound. Our quality commitment supports compliance with ICH Q2(R1) guidelines for analytical procedure validation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment. For long-term storage, consider desiccants or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.