Description

Nimodipine-D7 CAS NO 1246815-36-0 is a deuterated analog of the calcium channel blocker Nimodipine, where seven hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on neurovascular drug development and quality control.

Application

• Primary use as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and GC-MS bioanalysis.
• Quantification of Nimodipine and its metabolites in pharmacokinetic (PK) and pharmacodynamic (PD) studies.
• Essential for conducting drug metabolism and excretion (DMPK) research with high precision.
• Method development and validation in regulatory-compliant bioanalytical assays for clinical trials.
• Quality control and assurance in the manufacturing of Nimodipine-based pharmaceutical products.
• Use in specialized research investigating cerebral vasospasm and neuroprotective mechanisms.

Basic Information

Product Name	Nimodipine-D7
CAS No.	1246815-36-0
Molecular Formula	C21H19D7N2O7
Molecular Weight	433.48 g/mol (approx.)
Synonyms	1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester-d7; Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate-d7; Nimodipine-d7; Deuterated Nimodipine; Nimodipine (hexadeutero, methoxy-d); Bay e 9736-d7
EINECS	Contact for details

Quality Control

Every batch of Nimodipine-D7 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization using advanced techniques including NMR, HPLC, and MS. A Certificate of Analysis (COA) is provided with each shipment, detailing purity, isotopic enrichment, and analytical results. Our quality commitment ensures the material meets the stringent requirements for use in GLP and GMP-regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.