Description

Desacetyl Diltiazem-D3 is a deuterium-labeled internal standard of the active metabolite of the calcium channel blocker Diltiazem. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly in pharmacokinetic and metabolism studies. It is a critical tool for pharmaceutical R&D and clinical laboratories conducting precise LC-MS/MS analysis of Diltiazem and its metabolites.

Application

• Primary use as an internal standard for the quantification of Diltiazem and Desacetyl Diltiazem in biological matrices via LC-MS/MS.
• Critical component in pharmacokinetic (PK) studies and drug metabolism research to ensure data integrity.
• Enables accurate therapeutic drug monitoring (TDM) in clinical laboratory settings.
• Supports bioequivalence and bioavailability studies for generic drug development.
• Used in forensic and toxicological analysis for precise measurement of drug concentrations.
• Facilitates metabolite profiling and identification in advanced ADME research.

Basic Information

Product Name	Desacetyl Diltiazem-D3
CAS No.	1246815-32-6
Molecular Formula	C22H23D3N2O4S
Molecular Weight	~ 414.5 g/mol
Synonyms	(2S,3S)-5-[2-(Dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate-D3; Diltiazem Metabolite (Desacetyl) D3; Diltiazem-D3 (Desacetyl); Desacetyl Diltiazem Deuterated; (+)-cis-Desacetyl Diltiazem-D3; 3-Acetyloxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one-D3
EINECS	Contact for details

Quality Control

Our Desacetyl Diltiazem-D3 is manufactured under strict quality control protocols to ensure the high chemical purity and isotopic enrichment required for analytical standards. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic purity (D-enrichment), and impurity profile via validated methods such as HPLC, NMR, and MS. We adhere to relevant GMP principles for the production of reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Chemical Purity (by NMR)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.