Description

2-[(1S,2S)-1-Ethyl-2-(Phenylmethoxy)Propyl]-2,4-Dihydro-4-[4-[4-(4-o-Methoxymethyl-4-Hydroxyphenyl)-1-Piperazinyl]Phenyl]-3H-1,2,4-Triazol-3-One-D4 is a deuterated analog of a complex triazolone derivative, serving as a critical stable isotope-labeled internal standard for precise analytical quantification. This high-purity compound is essential for ensuring accuracy and reliability in sensitive mass spectrometry-based methods, particularly in regulated environments. It is primarily required by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers for pharmacokinetic studies, metabolite identification, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Used as a deuterium-labeled internal standard for the accurate quantification of the parent non-deuterated drug candidate in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Critical in studies to understand the absorption, distribution, metabolism, and excretion (ADME) profile of pharmaceutical compounds.
• Bioanalytical Method Development and Validation: Employed to develop and validate robust, GLP-compliant analytical methods for clinical and preclinical trials.
• Metabolite Profiling and Identification: Aids in distinguishing drug-derived metabolites from endogenous compounds in mass spectrometry analyses.
• Pharmaceutical Quality Control: Potentially used in impurity profiling and stability-indicating assay methods for drug substance and product analysis.

Basic Information

Product Name	2-[(1S,2S)-1-Ethyl-2-(Phenylmethoxy)Propyl]-2,4-Dihydro-4-[4-[4-(4-o-Methoxymethyl-4-Hydroxyphenyl)-1-Piperazinyl]Phenyl]-3H-1,2,4-Triazol-3-One-D4
CAS No.	1246815-26-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Deuterated Triazolone Derivative; Stable Isotope-Labeled Internal Standard (d4); (1S,2S)-1-Ethyl-2-(benzyloxy)propyl triazolone-d4; 4-[4-[4-(2-Methoxymethyl-4-hydroxyphenyl)piperazin-1-yl]phenyl]-2-[(1S,2S)-1-ethyl-2-(phenylmethoxy)propyl]-2,4-dihydro-3H-1,2,4-triazol-3-one-d4; Deuterated API Metabolite Standard; LC-MS Internal Standard-d4.
EINECS	Contact for details

Quality Control

This deuterated standard is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR (¹H, ¹³C, ²H) for structural and isotopic confirmation and High-Resolution Mass Spectrometry (HRMS). Certificates of Analysis (COA) are provided, detailing specifications for isotopic purity (atom % D), chemical purity (by HPLC), and identity confirmation, supporting compliance with GLP and GMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0% (by NMR/MS)
Chemical Purity (by NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.