Description

n-Desmethyl Trifluoperazine-D8 Dihydrochloride is a high-purity, deuterium-labeled internal standard critical for precise analytical quantification. This stable isotope-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based methods, particularly in regulated bioanalytical studies. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology labs for the development and validation of assays targeting trifluoperazine and its metabolites.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in LC-MS/MS and GC-MS methods for the accurate quantification of trifluoperazine and its metabolites in biological matrices (plasma, serum, urine).
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise tracking of drug metabolism and disposition in clinical and preclinical research.
• Forensic Toxicology: Used in method development for the confirmatory analysis of phenothiazine-derived pharmaceuticals in forensic casework.
• Drug Metabolism Research: Facilitates studies on the metabolic pathways and clearance mechanisms of trifluoperazine.
• Method Development & Validation: A key reagent for developing robust, compliant analytical methods according to FDA, EMA, and ICH guidelines.
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and stability testing of active pharmaceutical ingredients (APIs).

Basic Information

Item	Detail
Product Name	n-Desmethyl Trifluoperazine-D8 Dihydrochloride
CAS No.	1246814-84-5
Molecular Formula	C20H16D8Cl2F3N3S
Molecular Weight	480.43 g/mol
Synonyms	10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine-D8 Dihydrochloride; Trifluoperazine Desmethyl-D8 Dihydrochloride; Nor-Trifluoperazine-D8 Dihydrochloride; 2-Trifluoromethyl-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine-D8 Dihydrochloride; Trifluoperazine Impurity D8 Dihydrochloride; Deuterated Trifluoperazine Metabolite Standard; Internal Standard for Trifluoperazine Assay
EINECS	Contact for details

Quality Control

Every batch of n-Desmethyl Trifluoperazine-D8 Dihydrochloride is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity to meet the exacting demands of quantitative mass spectrometry. Certificates of Analysis (COA) are provided with each shipment, detailing results for assay, isotopic enrichment, and impurity profiles. Our quality commitment aligns with the standards expected for research use in GLP/GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere after each use to maintain long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥98 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.