Description

Cyclizine-D4 Hydrochloride CAS NO 1246814-82-3 is a deuterated isotopologue of the antiemetic drug cyclizine hydrochloride, where four hydrogen atoms are replaced by deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical measurements. It is a critical material for pharmaceutical research and development, clinical laboratories, and forensic toxicology studies requiring precise pharmacokinetic and metabolic profiling.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for drug level monitoring.
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of the parent drug cyclizine in biological matrices (plasma, serum, urine) during ADME research.
• Forensic & Clinical Toxicology: Used in analytical assays for the precise identification and quantification of cyclizine in cases of overdose or therapeutic drug monitoring.
• Pharmaceutical Quality Control: Supports method development and validation for the assay of cyclizine in active pharmaceutical ingredients (APIs) and finished dosage forms.
• Bioanalytical Method Development: Serves as a critical tool for developing and validating robust, GLP-compliant analytical methods in contract research organizations (CROs).
• Reference Material for Certified Standards: Used by manufacturers of certified reference materials (CRMs) to produce calibrated standards for regulatory submissions.

Basic Information

Product Name	Cyclizine-D4 Hydrochloride
CAS No.	1246814-82-3
Molecular Formula	C18H18D4ClN2•HCl
Molecular Weight	339.32 g/mol (approx.)
Synonyms	1-(Diphenylmethyl)-4-methyl-d4-piperazine Hydrochloride; Cyclizine-d4 HCl; [2H4]-Cyclizine Hydrochloride; N-Methyl-d4-piperazine, 1-(diphenylmethyl)-, hydrochloride; 1-(Diphenylmethyl)-4-(methyl-d4)piperazine Hydrochloride; Deuterated Cyclizine HCl; Cyclizine (phenyl-d5) Hydrochloride (related variant); Marzine-d4 Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Cyclizine-D4 Hydrochloride is manufactured and analyzed under strict quality systems to ensure it meets the exacting standards required for isotopic purity and chemical integrity in analytical applications. We provide comprehensive Certificates of Analysis (COA) detailing isotopic enrichment (D-content), chemical purity, and identity confirmation via orthogonal techniques. Our quality commitment supports compliance with ISO, GMP for APIs, and relevant ICH guidelines for analytical standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0% (chemical purity)
Isotopic Purity (D-content)	≥ 98.0 atom % D (by MS)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.