Description

n-tert-Butoxycarbonyl Amoxapine-D8 is a deuterated derivative of the tricyclic antidepressant amoxapine, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and bioequivalence studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities specializing in LC-MS/MS method development.

Application

• Internal Standard for LC-MS/MS Analysis: Critical for the precise quantification of amoxapine and its metabolites in complex biological matrices such as plasma, serum, and urine.
• Pharmaceutical Research & Development: Supports method validation, stability testing, and metabolic profiling during drug development processes.
• Forensic Toxicology: Used in confirmatory testing and accurate measurement of amoxapine levels in forensic casework.
• Clinical Trial Support: Enables reliable data generation for bioavailability, bioequivalence, and therapeutic drug monitoring studies.
• Metabolite Identification Studies: Aids in the structural elucidation and tracking of deuterated metabolites in in vitro and in vivo studies.
• Quality Control in API Manufacturing: Serves as a reference material for impurity profiling and assay verification of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	n-tert-Butoxycarbonyl Amoxapine-D8
CAS No.	1246814-71-0
Molecular Formula	C24H21D8N3O3
Molecular Weight	407.55 g/mol (for deuterated form)
Synonyms	Boc-Amoxapine-D8; 2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine-D8, N-Boc derivative; Amoxapine-D8 tert-Butyl Carbamate; tert-Butyl (2-chloro-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepin-6-yl)carbamate-D8; Deuterated Amoxapine Boc Derivative; Amoxapine N-Boc-D8; Internal Standard for Amoxapine LC-MS
EINECS	Contact for details

Quality Control

Every batch of n-tert-Butoxycarbonyl Amoxapine-D8 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity suitable for sensitive analytical applications. Comprehensive testing includes identity confirmation, assay determination, and control of related substances and residual solvents. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting lot-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.