Description

Nepafenac-D5 CAS NO 1246814-53-8 is a deuterated internal standard of the non-steroidal anti-inflammatory drug (NSAID) Nepafenac, specifically designed for analytical and research applications. This high-purity, isotopically labeled compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses, such as LC-MS/MS. It is a critical tool for pharmaceutical R&D, bioanalytical laboratories, and quality control units requiring precise measurement of Nepafenac in complex matrices like biological fluids and drug formulations.

Application

• Primary use as an internal standard for the accurate quantification of Nepafenac via Liquid Chromatography-Mass Spectrometry (LC-MS/MS).
• Critical component in pharmacokinetic and bioequivalence studies to measure drug concentrations in plasma, serum, and other biological samples.
• Essential for drug metabolism and stability studies in pharmaceutical research and development.
• Used in quality control and impurity profiling of Nepafenac active pharmaceutical ingredient (API) and finished drug products.
• Supports forensic and clinical toxicology analyses requiring definitive identification and measurement of Nepafenac.
• Facilitates method development and validation in analytical laboratories to meet regulatory guidelines (e.g., FDA, ICH).

Basic Information

Product Name	Nepafenac-D5
CAS No.	1246814-53-8
Molecular Formula	C15H9D5N2O2
Molecular Weight	257.31 g/mol
Synonyms	2-Amino-3-(benzoyl-d5)-N-phenylbenzamide; Deuterated Nepafenac; Nepafenac (phenyl-d5); Nepafenac-d5; 2-Amino-3-benzoyl-N-phenylbenzamide-d5; 3-(Benzoyl-d5)-2-amino-N-phenylbenzamide; Amfenac-d5; [phenyl-d5]-Nepafenac
EINECS	Contact for details

Quality Control

Our Nepafenac-D5 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm isotopic enrichment and chemical purity. A comprehensive Certificate of Analysis (COA) detailing assay, isotopic purity, and impurity profile is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated place. For long-term storage, consider storing desiccated under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (MS)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.