Description

Rac n-Benzyl Nebivolol-D4 CAS NO 1246814-48-1 is a deuterated isotopologue of a key nebivolol intermediate, specifically labeled at four positions. This compound serves as a critical internal standard for the precise quantification and metabolic study of nebivolol and its related substances in analytical chemistry. It is essential for researchers and quality control laboratories in the pharmaceutical industry requiring high-fidelity analytical reference materials for method development and validation.

Application

• Pharmaceutical Reference Standard: Primary use as a certified internal standard for the accurate quantification of nebivolol and its metabolites in biological matrices and pharmaceutical formulations via LC-MS/MS and GC-MS.
• Metabolic Pathway Tracing: Enables detailed pharmacokinetic and drug metabolism studies by tracking the deuterium label in in vitro and in vivo systems.
• Analytical Method Development: Critical for developing and validating robust, sensitive, and specific analytical methods in compliance with ICH Q2(R1) guidelines.
• Impurity Profiling and Characterization: Aids in the identification and quantification of process-related impurities and degradation products in active pharmaceutical ingredient (API) batches.
• Doping Control Analysis: Potential application as a reference compound in sports anti-doping laboratories for the detection of β-blocker misuse.

Basic Information

Product Name	Rac n-Benzyl Nebivolol-D4
CAS No.	1246814-48-1
Molecular Formula	C33H35D4F2NO4
Molecular Weight	547.66 g/mol (for D4 isotopologue)
Synonyms	1-(6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-[2-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-hydroxyethylamino]ethanol; Nebivolol n-Benzyl-D4; Nebivolol Benzyl-D4 Intermediate; rac-1-(6-Fluoro-3,4-dihydro-2H-chromen-2-yl)-2-{2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethylamino}ethan-1-ol; Deuterated Nebivolol Benzyl Intermediate; UNII-8JQ5607E5F (related)
EINECS	Contact for details

Quality Control

Every batch of Rac n-Benzyl Nebivolol-D4 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support its use as a high-purity reference material. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters including isotopic purity (D4 content), chemical purity (by HPLC), and identification (by NMR and MS). Our quality commitment ensures consistency and reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D4)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.