Description

Rac Efavirenz-D4 CAS NO 1246812-58-7 is a deuterated isotopologue of the non-nucleoside reverse transcriptase inhibitor (NNRTI) Efavirenz, where four hydrogen atoms are replaced with deuterium. This stable-labeled compound is an essential tool for quantitative bioanalytical research, providing superior accuracy and reliability in pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced drug development and analytical method validation.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical internal standard for the precise quantification of Efavirenz in biological matrices (plasma, serum, tissue) using liquid chromatography-tandem mass spectrometry.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracking of the parent drug's absorption, distribution, metabolism, and excretion (ADME) profile without interference from endogenous compounds.
• Bioanalytical Method Development and Validation: Used as a reference standard to develop, optimize, and validate robust, regulatory-compliant (FDA, EMA) bioanalytical assays.
• Clinical Trial Support: Facilitates reliable drug concentration monitoring in patient samples during clinical trials for antiretroviral therapies.
• Metabolite Identification and Profiling: Aids in distinguishing drug-derived metabolites from background signals in complex mass spectrometric analyses.
• Quality Control in Reference Standard Production: Acts as a calibrant or system suitability check in the quality control of non-deuterated pharmaceutical reference standards.

Basic Information

Product Name	Rac Efavirenz-D4
CAS No.	1246812-58-7
Molecular Formula	C14H5D4ClF3NO2
Molecular Weight	319.71 g/mol (for D4 isotopologue)
Synonyms	(±)-Efavirenz-D4; Efavirenz (D4); 8-Chloro-5-(2-cyclopropylethynyl)-5-(trifluoromethyl)-2,4(1H,3H)-dioxopyrido[3,2-b][1,4]oxazin-6(5H)-one-D4; 8-Chloro-5-[(1S)-2-cyclopropylethynyl]-5-(trifluoromethyl)-2,4-dihydro-1,5H-oxazolo[3,4-b]pyridin-6-one-D4 (racemic); DMP 266-D4; Sustiva-D4 (labeled); NNRTI-D4 (labeled); Stable Isotope Labeled Efavirenz.
EINECS	Contact for details

Quality Control

Our Rac Efavirenz-D4 is manufactured under strict quality systems to ensure high chemical and isotopic purity suitable for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm identity, chemical purity, and deuterium incorporation. Comprehensive Certificates of Analysis (COA) detailing batch-specific results for assay, isotopic enrichment, and related substances are provided to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider storing under inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D4)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.