Description

3,3-Difluorocyclobutanecarbaldehyde is a versatile fluorinated building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity of the aldehyde group combined with the steric and electronic properties imparted by the difluorocyclobutane ring, enabling the construction of complex molecular architectures. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting enzyme inhibition or receptor modulation.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine atoms can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Employed in the synthesis of fluorinated polymers or liquid crystals with tailored properties.
• Chemical Biology Probe Synthesis: Utilized to create fluorinated analogs of biomolecules for studying biological pathways and interactions.

Basic Information

Product Name	3,3-Difluorocyclobutanecarbaldehyde
CAS No.	1246765-49-0
Molecular Formula	C5H6F2O
Molecular Weight	120.10 g/mol
Synonyms	3,3-Difluorocyclobutanecarboxaldehyde; 3,3-Difluorocyclobutane-1-carbaldehyde; Cyclobutanecarboxaldehyde, 3,3-difluoro-; 3,3-Difluorocyclobutanecarbonal
EINECS	Contact for details

Quality Control

Our 3,3-Difluorocyclobutanecarbaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chromatographic purity analysis and structural confirmation, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated area. Recommended storage temperature is 2-8°C for long-term stability. Allow the sealed container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.