Description

tert-Butyl 3-(Pyrrolidin-1-Yl)Cyclobutylcarbamate is a high-purity, advanced pharmaceutical intermediate featuring a cyclobutane core functionalized with a pyrrolidine and a Boc-protected amine. This compound is critical for medicinal chemistry research and development, offering a versatile scaffold for constructing novel bioactive molecules. It is primarily utilized by pharmaceutical companies and research institutions engaged in the synthesis of new chemical entities for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of small molecule drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to explore new pharmacophores.
• Protease Inhibitor Development: Serves as a precursor for compounds targeting various protease enzymes.
• Kinase Inhibitor Synthesis: Employed in the construction of novel kinase inhibitor scaffolds for oncology research.
• Peptidomimetic Chemistry: The cyclobutylcarbamate structure is valuable for creating conformationally constrained peptide analogs.
• Chemical Biology Probes: Used to develop tool compounds for investigating biological pathways and target validation.

Basic Information

Product Name	tert-Butyl 3-(Pyrrolidin-1-Yl)Cyclobutylcarbamate
CAS No.	1246739-82-1
Molecular Formula	C13H24N2O2
Molecular Weight	240.34 g/mol
Synonyms	1,1-Dimethylethyl 3-(1-pyrrolidinyl)cyclobutanecarboxylate; 3-(Pyrrolidin-1-yl)cyclobutanamine, N-BOC derivative; tert-Butyl N-[3-(pyrrolidin-1-yl)cyclobutyl]carbamate; Boc-3-(pyrrolidin-1-yl)cyclobutylamine; N-Boc-3-(1-pyrrolidinyl)cyclobutanamine; 3-(1-Pyrrolidinyl)cyclobutanamine, N-BOC-protected; 1246739-82-1; Cyclobutanecarboxylic acid, 3-(1-pyrrolidinyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(Pyrrolidin-1-Yl)Cyclobutylcarbamate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC, to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and consistency for your critical R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.