Description

5-Fluoro-2-Hydroxymethylphenylboronic Acid is a high-purity, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functional groups, which enable its use as a versatile coupling partner in cross-coupling reactions and as a precursor for more complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for developing active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing complex biaryl structures found in drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific fluorinated phenyl motifs.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized boronic ester ligands and organocatalysts.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs and sensors.
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological processes and protein interactions.
• Custom Synthesis and Contract Manufacturing: A valuable reagent for CROs and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	5-Fluoro-2-Hydroxymethylphenylboronic Acid
CAS No.	1246633-53-3
Molecular Formula	C7H8BFO3
Molecular Weight	169.95 g/mol
Synonyms	(5-Fluoro-2-(hydroxymethyl)phenyl)boronic acid; 2-(Hydroxymethyl)-5-fluorobenzeneboronic acid; 5-Fluoro-2-(hydroxymethyl)benzeneboronic acid; 5-Fluoro-2-hydroxymethylbenzeneboronic Acid; B-(5-Fluoro-2-(hydroxymethyl)phenyl)boronic acid; 1246633-53-3; 5-Fluoro-2-Hydroxymethyl Phenylboronic Acid
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Hydroxymethylphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications in GMP-aligned environments and research requiring reliable, consistent material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.