Description

4-Chloro-3-Fluoro-2-Formylphenylboronic Acid Pinacol Ester is a high-value, multi-functional boronic ester building block designed for advanced organic synthesis. Its core value lies in providing a protected boronic acid functionality alongside a reactive aldehyde group, enabling sequential cross-coupling and subsequent derivatization in a single molecule. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of complex, multi-substituted biaryl compounds used in drug discovery and development.
• Agrochemical Synthesis: Used in creating novel active ingredients for crop protection products, leveraging its halogen and boronate functionalities.
• Material Science Research: Serves as a precursor for functionalized organic materials, such as ligands for catalysts or monomers for specialty polymers.
• Suzuki-Miyaura Cross-Coupling: The pinacol ester protects the boronic acid, enhancing stability and handling for efficient palladium-catalyzed C-C bond formation.
• Sequential Functionalization: The formyl (aldehyde) group allows for further chemical transformations (e.g., reductive amination, condensation) after the cross-coupling step.
• Library Synthesis: Ideal for generating diverse compound libraries in medicinal chemistry due to its two orthogonal reactive sites.

Basic Information

Product Name	4-Chloro-3-Fluoro-2-Formylphenylboronic Acid Pinacol Ester
CAS No.	1246632-88-1
Molecular Formula	C₁₃H₁₅BClFO₃
Molecular Weight	283.52 g/mol
Synonyms	(4-Chloro-3-fluoro-2-formylphenyl)boronic acid pinacol ester; 2-Formyl-4-chloro-3-fluorophenylboronic acid pinacol ester; 4-Chloro-3-fluoro-2-formylbenzeneboronic acid pinacol ester; Pinacol (4-chloro-3-fluoro-2-formylphenyl)boronate; B-(4-Chloro-3-fluoro-2-formylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; CAS 1246632-88-1
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-3-Fluoro-2-Formylphenylboronic Acid Pinacol Ester adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. Every lot is fully characterized by NMR (¹H, ¹³C, ¹¹B), HPLC, and GC to confirm identity, assay, and impurity profiles. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment. We support cGMP manufacturing standards for advanced intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C (refrigerated) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.