Description

Omega(7-Nitro-2-1,3-Benzoxadiazol-4-Yl)-n-Stearoyl-D-Erythro-Sphingosine (CAS NO 1246303-04-7) is a high-purity, fluorescently labeled sphingolipid derivative, specifically designed for advanced biochemical research and diagnostic applications. This compound is critical for studying lipid metabolism, membrane dynamics, and cellular signaling pathways due to its specific fluorescence properties. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors for probe development, assay kits, and high-sensitivity detection methods.

Application

• Fluorescent Lipid Probes: Used as a critical component in the synthesis of fluorescent probes for tracking sphingolipid distribution, trafficking, and metabolism in live-cell imaging and flow cytometry.
• Biochemical Assay Development: Serves as a key standard or labeled substrate in enzymatic assays (e.g., for sphingomyelinases or ceramidases) and in vitro diagnostic (IVD) kit development.
• Lipidomics Research: Employed as an internal standard or a labeled analog in mass spectrometry-based lipidomics to quantify and profile complex biological samples with high accuracy.
• Cell Biology Studies: Facilitates the investigation of apoptosis, autophagy, and other cell death mechanisms where ceramide and sphingolipid signaling play a central role.
• Drug Discovery Screening: Acts as a target or tracer in high-throughput screening (HTS) platforms to identify modulators of sphingolipid-related enzymes or receptors.
• Diagnostic Reagent Manufacturing: Incorporated into specialized reagents for clinical diagnostics targeting lipid metabolic disorders.

Basic Information

Product Name	Omega(7-Nitro-2-1,3-Benzoxadiazol-4-Yl)-n-Stearoyl-D-Erythro-Sphingosine
CAS No.	1246303-04-7
Molecular Formula	C47H80N4O6
Molecular Weight	797.17 g/mol
Synonyms	NBD C18-Ceramide; N-Stearoyl-NBD-Ceramide; 7-Nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) Labeled C18-Ceramide; N-Octadecanoyl-NBD-D-erythro-sphingosine; NBD Fluorescent Ceramide (C18); NBD-Cer (d18:1/18:0); Fluorescent Sphingolipid Probe; NBD-C18 Ceramide
EINECS	Contact for details

Quality Control

Our Omega(7-Nitro-2-1,3-Benzoxadiazol-4-Yl)-n-Stearoyl-D-Erythro-Sphingosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and functional validation for fluorescence performance. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring traceability and compliance with research-grade material standards. Custom purity grades and bulk quantities are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep the container sealed under an inert atmosphere (e.g., argon or nitrogen) to maintain stability and prevent degradation. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid or film
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with molecular structure
Purity (HPLC)	≥ 98.0% (Area Percent)
Fluorescence Properties	Excitation/Emission maxima consistent with NBD label
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, ethanol, DMF; slightly soluble in chloroform

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.