Description

1-(Difluoromethoxy)-4-Methyl-2-Nitrobenzene is a specialized fluorinated aromatic nitro compound, serving as a valuable building block in advanced organic synthesis. Its unique difluoromethoxy and nitro-substituted benzene core makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This high-purity intermediate is essential for research and production in pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorinated motifs for enhanced bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting fluorinated small molecules.
• Agrochemical Synthesis: Building block for developing next-generation herbicides, fungicides, and insecticides where the difluoromethoxy group can improve efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Used in the research and production of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Advanced Polymer Chemistry: Monomer or modifier for creating specialty polymers with specific thermal, chemical, or surface properties.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D exploring new fluorination methodologies and aromatic substitution reactions.
• Dye & Pigment Intermediate: Potential starting material for synthesizing specialized nitro- and fluoro-containing dyes and pigments.

Basic Information

Item	Detail
Product Name	1-(Difluoromethoxy)-4-Methyl-2-Nitrobenzene
CAS No.	1245772-51-3
Molecular Formula	C8H7F2NO3
Molecular Weight	203.14 g/mol
Synonyms	4-Methyl-2-nitro-1-(difluoromethoxy)benzene; 2-Nitro-4-methylphenyl difluoromethyl ether; α,α-Difluoro-2-nitro-p-cresyl methyl ether; 1-(Difluoromethoxy)-4-methyl-2-nitro-benzene; Difluoromethoxy(4-methyl-2-nitrophenyl) ether
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethoxy)-4-Methyl-2-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be opaque or stored in darkness.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.