Description

6-Bromo-2-Cyclopropylisoindolin-1-One is a high-value, advanced pharmaceutical intermediate characterized by its unique isoindolinone core functionalized with bromine and cyclopropyl groups. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of small-molecule therapeutics, particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degraders.
• Kinase Inhibitor Synthesis: Employed in the synthesis of potential kinase inhibitors due to the privileged isoindolinone structure.
• Agrochemical Research: Investigated as an intermediate for developing new crop protection agents with novel modes of action.
• Material Science: Explored as a monomer or precursor for specialty polymers and advanced organic electronic materials.

Basic Information

Product Name	6-Bromo-2-Cyclopropylisoindolin-1-One
CAS No.	1245649-56-2
Molecular Formula	C11H10BrNO
Molecular Weight	252.11 g/mol
Synonyms	6-Bromo-2-cyclopropyl-2,3-dihydro-1H-isoindol-1-one; 2-Cyclopropyl-6-bromoisoindolin-1-one; 6-Bromo-2-cyclopropylisoindolinone; 1H-Isoindol-1-one, 6-bromo-2-cyclopropyl-2,3-dihydro-; 1245649-56-2
EINECS	Contact for details

Quality Control

Our 6-Bromo-2-Cyclopropylisoindolin-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) detailing purity, impurities, and full characterization data are provided with every shipment to support your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.