Description

2-(Trifluoromethyl)Piperidin-4-Ol is a high-value, fluorinated piperidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring a trifluoromethyl group and a hydroxyl moiety on the piperidine ring, makes it indispensable for modulating the physicochemical properties of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of central nervous system (CNS) active drugs, protease inhibitors, and other bioactive molecules.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and liquid crystals where fluorine incorporation alters material properties.
• Chemical Biology & Proteomics: Useful as a building block for activity-based probes and molecular tags.

Basic Information

Product Name	2-(Trifluoromethyl)Piperidin-4-Ol
CAS No.	1245644-81-8
Molecular Formula	C6H10F3NO
Molecular Weight	169.15 g/mol
Synonyms	4-Hydroxy-2-(trifluoromethyl)piperidine; 2-(Trifluoromethyl)-4-piperidinol; 2-Trifluoromethyl-4-hydroxypiperidine; α,α,α-Trifluoro-4-piperidinol; 4-Piperidinol, 2-(trifluoromethyl)-; 1245644-81-8; 2-TFM-4-OH-Piperidine
EINECS	Contact for details

Quality Control

Every batch of 2-(Trifluoromethyl)Piperidin-4-Ol is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral purity analysis, to ensure compliance with exacting customer and research standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.