Description

3-Chloro-5-Fluoro-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzene is a high-purity, advanced pharmaceutical intermediate and versatile organoboron building block. This compound is critical for facilitating efficient cross-coupling reactions, enabling the rapid synthesis of complex molecules for drug discovery and material science. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for constructing biaryl and heterobiaryl scaffolds prevalent in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: Used in the synthesis of potential drug candidates targeting a range of therapeutic areas, including oncology and CNS disorders.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology Probes: Utilized for labeling and modifying biomolecules in proteomics and diagnostic assay development.
• Process Chemistry & Scale-Up: Provides a reliable and consistent starting material for kilo-lab and pilot plant production.

Basic Information

Product Name	3-Chloro-5-Fluoro-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzene
CAS No.	1245524-02-0
Molecular Formula	C12H15BClFO2
Molecular Weight	255.51 g/mol
Synonyms	(3-Chloro-5-fluorophenyl)boronic acid pinacol ester; 3-Chloro-5-fluorophenylboronic acid pinacol ester; 2-(3-Chloro-5-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Chloro-5-fluoro-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene; 3-Chloro-5-fluorophenyl-Bpin; Pinacol (3-chloro-5-fluorophenyl)boronate; B-(3-Chloro-5-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-5-Fluoro-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzene is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including NMR, HPLC, and GC-MS, to ensure high chemical purity and lot-to-lot consistency essential for sensitive coupling reactions. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent hydrolysis and maintain reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.