Description

4-Benzyloxy-3-(Trifluoromethyl)Phenylboronicacid is a high-value, synthetically versatile boronic acid derivative. This compound serves as a critical building block in modern organic synthesis, particularly in cross-coupling reactions to form new carbon-carbon bonds. It is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries seeking to introduce the 4-benzyloxy-3-(trifluoromethyl)phenyl moiety into complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), especially those containing trifluoromethyl groups for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the benzyloxy and trifluoromethyl functionalities can impart specific biological activity.
• Ligand & Catalyst Synthesis: Building block for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science: Monomer or precursor in the synthesis of organic electronic materials, such as those used in OLEDs or semiconductors, where its structure can influence charge transport properties.
• Chemical Biology & Probe Development: Useful for synthesizing molecular probes and tags for studying biological processes, leveraging the boronic acid group's ability to bind diols.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CMOs for client-directed synthesis projects requiring this specific boronic acid scaffold.

Basic Information

Product Name	4-Benzyloxy-3-(Trifluoromethyl)Phenylboronicacid
CAS No.	1245014-05-4
Molecular Formula	C14H12BF3O3
Molecular Weight	296.05 g/mol
Synonyms	[4-(Benzyloxy)-3-(trifluoromethyl)phenyl]boronic acid; 3-Trifluoromethyl-4-benzyloxyphenylboronic acid; 4-(Benzyloxy)-3-(trifluoromethyl)benzeneboronic acid; B-[4-(Phenylmethoxy)-3-(trifluoromethyl)phenyl]boronic acid; 4-Benzyloxy-3-trifluoromethylphenylboronic Acid; (4-Benzyloxy-3-trifluoromethylphenyl)boronic acid; 4-(Benzyloxy)-α,α,α-trifluoro-m-tolylboronic acid
EINECS	Contact for details

Quality Control

Our 4-Benzyloxy-3-(Trifluoromethyl)Phenylboronicacid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the primary container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.