Description

2-Chloro-5-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester group. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry for constructing complex biaryl scaffolds. It is primarily utilized by R&D and process chemistry teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: Essential reagent for forming carbon-carbon bonds between aromatic rings, enabling the creation of diverse biaryl structures.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with complex molecular architectures.
• Material Science: Potential precursor for organic electronic materials and ligands in catalytic systems.
• Chemical Synthesis: Versatile intermediate for academic and industrial research in organic and medicinal chemistry.

Basic Information

Product Name	2-Chloro-5-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline
CAS No.	1244039-65-3
Molecular Formula	C12H16BClFNO2
Molecular Weight	271.53 g/mol
Synonyms	2-Chloro-5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine; 3-Amino-2-chloro-5-fluorophenylboronic acid pinacol ester; (3-Amino-2-chloro-5-fluorophenyl)boronic acid pinacol ester; 2-Chloro-5-fluoro-3-(pinacolatoboryl)aniline; 1244039-65-3; Benzenamine, 2-chloro-5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.