Description

Fmoc-n-Et-Ile-Oh CAS NO 1243654-95-6 is a protected, non-proteinogenic amino acid derivative, specifically an N-ethylated isoleucine analog with an Fmoc (9-fluorenylmethoxycarbonyl) protecting group on the α-amine. This compound is a critical building block in modern solid-phase peptide synthesis (SPPS), enabling the precise incorporation of modified amino acid residues to engineer peptides with enhanced stability, bioavailability, or specific biological activity. It is essential for research and development laboratories in the pharmaceutical, biotechnology, and agrochemical sectors focused on creating novel peptide-based therapeutics, diagnostics, and active ingredients.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated, sequential assembly of custom peptide sequences.
• Pharmaceutical Research: Used to synthesize peptide drug candidates with improved metabolic stability by incorporating N-alkylated amino acids.
• Peptidomimetic Design: Serves as a precursor for creating non-natural peptide analogs that mimic protein structures for drug discovery.
• Bioconjugation & Labeling: The Fmoc group allows for orthogonal deprotection strategies, facilitating site-specific modifications of peptides.
• Combinatorial Chemistry Libraries: Employed in generating diverse libraries of peptide-like compounds for high-throughput screening.
• Academic & Institutional Research: Fundamental tool for studying protein-protein interactions, enzyme substrates, and receptor ligands.

Basic Information

Product Name	Fmoc-n-Et-Ile-Oh
CAS No.	1243654-95-6
Molecular Formula	C24H29NO5
Molecular Weight	411.49 g/mol
Synonyms	Fmoc-N-ethylisoleucine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-ethyl-L-isoleucine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-methylpentanoic acid; Fmoc-N(Et)-Ile-OH; Fmoc-N-ethyl-Ile-OH; Nα-Fmoc-Nα-ethyl-L-isoleucine; N-Fmoc-N-ethyl-L-isoleucine
EINECS	Contact for details

Quality Control

Our Fmoc-n-Et-Ile-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for sensitive peptide synthesis applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.