Description

4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-2-Trifluoromethyl-Phenol is a high-value, multi-functional boronic ester derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura coupling, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require precise, reliable building blocks for drug discovery, ligand synthesis, and the development of novel functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those containing trifluoromethyl and phenolic motifs for enhanced bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the boronic ester group for efficient coupling to create diverse heterocyclic structures.
• Material Science & OLED Development: Serves as a precursor for creating organic light-emitting diode (OLED) materials, liquid crystals, and polymers where the phenol and boronate functionalities allow for precise molecular engineering.
• Cross-Coupling Reactions (Suzuki-Miyaura): The protected boronic acid group makes it an ideal, air-stable reagent for palladium-catalyzed carbon-carbon bond formation under mild conditions.
• Ligand and Catalyst Design: Utilized in the development of novel bidentate ligands and organocatalysts for asymmetric synthesis and transition metal catalysis.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the synthesis of molecular probes for studying biological processes.

Basic Information

Product Name	4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-2-Trifluoromethyl-Phenol
CAS No.	1243143-45-4
Molecular Formula	C13H16BF3O3
Molecular Weight	288.07 g/mol
Synonyms	2-Trifluoromethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)phenol; 2-(Trifluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; Pinacol (2-Hydroxy-5-(trifluoromethyl)phenyl)boronate; (2-Hydroxy-5-(trifluoromethyl)phenyl)boronic acid pinacol ester; 4-Borono-2-(trifluoromethyl)phenol pinacol ester
EINECS	Contact for details

Quality Control

Our 4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-2-Trifluoromethyl-Phenol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.