Description

L-Norvaline, n-[(1,1-Dimethylethoxy)Carbonyl]-5-(Methylthio)- is a protected amino acid derivative, specifically a Boc-protected norvaline analog with a methylthio side chain. This compound is a critical building block in the synthesis of complex peptides and modified amino acids, offering precise control over molecular structure and function. It is primarily needed by pharmaceutical research and fine chemical synthesis laboratories for developing novel therapeutic agents and biochemical tools.

Application

• Pharmaceutical Intermediates: Key precursor in the synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate modified norvaline residues.
• Biochemical Research: Serves as a non-proteinogenic amino acid analog in enzyme inhibition studies and metabolic pathway research.
• Proteomics & Labeling: Potential building block for creating affinity tags, probes, or isotopically labeled compounds for mass spectrometry.
• Agrochemical Synthesis: Intermediate in the development of specialized herbicides or plant growth regulators with amino acid backbones.
• Material Science: Monomer for synthesizing novel polymers with specific functional groups derived from the methylthio moiety.

Basic Information

Item	Details
Product Name	L-Norvaline, n-[(1,1-Dimethylethoxy)Carbonyl]-5-(Methylthio)-
CAS No.	1242340-22-2
Molecular Formula	C11H21NO4S
Molecular Weight	263.35 g/mol
Synonyms	Boc-S-Methyl-L-homocysteine; (S)-2-((tert-Butoxycarbonyl)amino)-5-(methylthio)pentanoic acid; Boc-L-Met(OMe)-OH (incorrect but common misnomer); N-Boc-5-(Methylthio)-L-norvaline; tert-Butyl (S)-5-(methylthio)-2-((tert-butoxycarbonyl)amino)pentanoate (related ester); Boc-Homocysteine(Methyl)-OH; N-(tert-Butoxycarbonyl)-5-(methylthio)-L-norvaline
EINECS	Contact for details

Quality Control

Our L-Norvaline, n-[(1,1-Dimethylethoxy)Carbonyl]-5-(Methylthio)- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR, and MS for structural confirmation, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.