Description

6-Chloro-2,4-Difluoroiodobenzene is a high-purity, multi-halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring chlorine, fluorine, and iodine substituents, makes it a versatile and valuable intermediate for constructing complex molecules. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting fluorine-containing bioactive molecules.
• Agrochemical Research: Used to develop new herbicides, fungicides, and pesticides where the difluoro and chloro groups can enhance biological activity and environmental stability.
• Ligand Synthesis: Serves as a starting material for the preparation of specialized ligands used in catalysis and material science.
• Functional Material Development: Employed in the creation of organic electronic materials, liquid crystals, and advanced polymers.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form complex biaryl structures.
• Chemical Biology Probes: Useful for synthesizing tagged molecules or probes for biochemical and diagnostic applications.

Basic Information

Item	Details
Product Name	6-Chloro-2,4-Difluoroiodobenzene
CAS No.	1242339-98-5
Molecular Formula	C6H2ClF2I
Molecular Weight	274.44 g/mol
Synonyms	1-Chloro-3,5-difluoro-2-iodobenzene; 2,4-Difluoro-6-chloroiodobenzene; 2-Iodo-1,3-difluoro-5-chlorobenzene; 3,5-Difluoro-2-iodochlorobenzene; Benzene, 1-chloro-3,5-difluoro-2-iodo-; (3,5-Difluoro-2-iodophenyl)chloride; 6-Chloro-2,4-difluoro-1-iodobenzene
EINECS	Contact for details

Quality Control

Our 6-Chloro-2,4-Difluoroiodobenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.