Description

5-Bromo-4-Chloro-2-(Trifluoromethyl)Benzonitrile is a high-value, multi-functional aromatic intermediate featuring bromo, chloro, and trifluoromethyl substituents. This compound is critical for its role in facilitating complex molecular transformations, particularly in the synthesis of advanced pharmaceutical and agrochemical active ingredients. It is primarily sought by R&D chemists and process development scientists in the life sciences sector for constructing novel chemical entities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromo and chloro substituents make it an excellent substrate for selective palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl structures.
• Fluorine Chemistry Research: An important compound for studying the effects of fluorine substitution on molecular properties like lipophilicity, bioavailability, and chemical reactivity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	5-Bromo-4-Chloro-2-(Trifluoromethyl)Benzonitrile
CAS No.	1242339-26-9
Molecular Formula	C8H2BrClF3N
Molecular Weight	284.46 g/mol
Synonyms	2-Bromo-1-chloro-4-cyano-5-(trifluoromethyl)benzene; 4-Bromo-5-chloro-2-(trifluoromethyl)benzonitrile; 5-Bromo-4-chloro-2-(trifluoromethyl)benzonitrile; Benzonitrile, 5-bromo-4-chloro-2-(trifluoromethyl)-; 2-(Trifluoromethyl)-5-bromo-4-chlorobenzonitrile
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-4-Chloro-2-(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.