Description

3,4-Difluoro-2-Trifluoromethyl-Bromobenzene is a high-purity, multi-functional halogenated aromatic building block essential for advanced chemical synthesis. Its unique structure, featuring bromine, fluorine, and a trifluoromethyl group, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by R&D and process development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing fluorine and trifluoromethyl motifs known to enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the halogenated benzene core contributes to efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or functionalization agent in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Stille) to form complex biaryl structures.
• Fluorinated Compound Library: A valuable reagent for medicinal chemistry and discovery research aimed at building diverse libraries of fluorinated compounds for screening.
• Chemical Research & Development: Employed in academic and industrial R&D settings for methodological studies and the exploration of new synthetic pathways involving halogenated aromatics.

Basic Information

Product Name	3,4-Difluoro-2-Trifluoromethyl-Bromobenzene
CAS No.	1242339-23-6
Molecular Formula	C8H2BrF5
Molecular Weight	276.99 g/mol
Synonyms	2-Bromo-3,4-difluorobenzotrifluoride; 1-Bromo-2,3-difluoro-4-(trifluoromethyl)benzene; 3,4-Difluoro-2-(trifluoromethyl)bromobenzene; 2,3-Difluoro-α,α,α-trifluoro-4-bromotoluene; 4-Bromo-2,3-difluorobenzotrifluoride; Benzene, 1-bromo-2,3-difluoro-4-(trifluoromethyl)-; (2,3-Difluorophenyl)(bromo)trifluoromethane
EINECS	Contact for details

Quality Control

Our 3,4-Difluoro-2-Trifluoromethyl-Bromobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical characteristics are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to its organic solvent nature and halogenated structure, appropriate chemical storage cabinets are recommended.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.